Use of Human Polymerized Hemoglobin Solution to Augment Acute Normovolemic Hemodilution, Replace Surgical Blood Loss, and Manage Acute Postoperative Blood Loss for a Jehovah's Witness

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Use of Human Polymerized Hemoglobin Solution to Augment Acute Normovolemic Hemodilution, Replace Surgical Blood Loss, and Manage Acute Postoperative Blood Loss for a Jehovah's Witness

Significant progress has been made in the development of oxygen-carrying hemoglobin solutions for therapeutic use. Religious objection to donor red blood cells in the setting of perioperative blood loss and anemia is one of several potential uses of these products. Here we present a case in which a polymerized hemoglobin solution was used on a compassionate care basis to augment acute normovole...

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Extreme intraoperative blood loss and hemodilution in a Jehovah's Witness: new aspects in postoperative management.

1. Rosow C, Manberg PJ: Bispectral Index Monitoring. Anesthesiology Clinics of North America: Ann Anesth Pharmacol 1998; 2:89–107 2. Glass P, Bloom M, Kearse L, Rosow C, Sebel P, Manberg P: Bispectral analysis measures sedation and memory effects of propofol, midazolam, isoflurane, and alfenanil in healthy volunteers. ANESTHESIOLOGY 1997; 86:836–47 3. England MR, Murphy MC, Court M: How much is...

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Successful use of a polymerized hemoglobin blood substitute in a critically anemic Jehovah's Witness.

A stable, polymerized hemoglobin product has been formulated that overcomes the three traditional hurdles of hemoglobin-based blood substitutes: nephrotoxicity, osmotic diuresis, and blood-borne pathogens. We present a case of a patient with persistent colonic bleeding and a hemoglobin of 2.9 g/100 mL. Since her religious faith prevented her from accepting blood products, we offered a hemoglobi...

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Acute Normovolemic Hemodilution: A Practical Approach

Justifications: Perioperative allogeneic blood transfusion can be reduced or even completely avoided by using a set of different strategies: meticulous hemostasis, the use of pharmaceutical agents that assist in the process of coagulation/ fibrinolysis, the use of blood substitutes, induced hypotension, preoperative autologous blood donation, collection and reinfusion of autologous blood during...

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Recurarization after Acute Intraoperative Normovolemic Hemodilution and Use of Sugammadex.

Acute normovolemic hemodilution (ANH) is a blood conservation procedure that can be used in cases of refusal of blood transfusion for religious reasons. Herein, we describe a case of recurarization after reinfusion of collected blood. A combination of rocuronium/sugammadex has the potential to increase the safety of patients if ANH is done after induction. Prospective controlled studies evaluat...

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ژورنال

عنوان ژورنال: Journal of Blood Disorders & Transfusion

سال: 2015

ISSN: 2155-9864

DOI: 10.4172/2155-9864.1000307